[citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. The therapeutic response is related to the pathological subtype and several factors, such as old age, high grade histology, bulky lymph nodes, higher IPI score, and advanced stage [22, 24, 25]. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. Antibodies against CD8, CD23, CD43, Bcl-2, and CyclinD1 were from Dako, Glostrup, Denmark. https://doi.org/10.1016/j.ijom.2010.03.029. In our case, the late stage of disease, the morphologically blastic variant [44], and involvement of neck lymph nodes were all factors that contributed to poor prognosis of this patient. Sinus hyperplasia may be associated with non-hematolymphoid malignancy. Asian Pac J Cancer Prev. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. The cortex is also divided into outer cortex and inner cortex (also known as the paracortex). 2013;91 Thesis 5:127. Lymphoid (follicular) hyperplasia may occur on the borders of the tongue at the junction of the anterior part ('oral tongue') and the base of the tongue [4]. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. M Gromet, M J Homer, B L Carter Published Online: Sep 1 1982 https://doi.org/10.1148/radiology.144.4.7111732 PDF Share Article History Published in print: 1982 Figures References Related Details Vol. As stated before, the depth of invasion is a major prognostic indicator. The site is secure. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Lee YY, Van Tassel P, Nauert C, North LB, Jing BS. Postoperatively the patient was deemed unsafe for extubation and transferred to the intensive care unit while placed on high-dose intravenous dexamethasone. The tumour cell composition of MCL varies greatly in the literature, from small cells with slightly irregular nuclei to large cells similar to the large cells in DLBCL, which could be misdiagnosed as DLBCL. Before 2017;58:203342. One case presented as multiple deep ulcers. https://doi.org/10.1038/modpathol.2011.45. CD30 antibodies were purchased from Maixin Biotech. As they mount an immune response, lymphoid cells can proliferate and enlarge. When oral aggregates appear in clusters or have an unusual appearance or enlargement, clinicians may question whether abnormalities are present. Two patients survived more than six years. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. Bone marrow biopsy is necessary to rule out CNS involvement. None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). Before This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. What are chaces of malignancy?What precautions for future shud i take? It provides context as to what an oral pathologist might see that aides in excludingnonreactive or neoplastic lesions. Cancer that develops in the base of the tongue is a type of head and neck cancer. This entity was first described in 1973 by Adkins. c. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (40 x) d. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (100 x). DLBCL with high risk factors and MCL may have unfavourable outcomes. Call your doctor or 911 if you think you may have a medical emergency. Jrvenp P, Ilmarinen T, Geneid A, Pietarinen P, Kinnari TJ, Rihkanen H, Ruohoalho J, Markkanen-Leppnen M, Bck L, Arkkila P, Aaltonen LM. 2005;29:128493. Neville BW, Damm DD, Allen CM, Chi AC. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. This may be because the case occurred before drugs such as rituximab were widely available. The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. official website and that any information you provide is encrypted Clinical information and disease characteristics are described in Table1. Tumours in this site are predominantly DLBCL subtypes in histology. Jain KS, Sikora AG, Baxi SS, Morris LG. Video chat with a U.S. board-certified doctor 24/7 in a minute. https://doi.org/10.1097/01.dad.0000246949.49071.17. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status, https://doi.org/10.1186/s13000-020-00936-w, https://doi.org/10.1016/S0344-0338(11)80514-5, https://doi.org/10.1016/j.kjms.2012.02.014, https://doi.org/10.1080/02841860500531682, https://doi.org/10.1038/modpathol.2016.152, https://doi.org/10.1007/s00428-014-1682-7, https://doi.org/10.1038/modpathol.2011.45, https://doi.org/10.1182/blood-2003-05-1545, https://doi.org/10.1038/modpathol.3880541, https://doi.org/10.1097/01.dad.0000246949.49071.17, https://doi.org/10.1007/s12185-008-0142-z, https://doi.org/10.1016/j.ijom.2004.08.009, https://doi.org/10.1016/j.ijom.2010.03.029, https://doi.org/10.1016/j.anndiagpath.2005.09.020, https://doi.org/10.1016/j.oooo.2014.06.002, https://doi.org/10.1007/978-3-319-22822-8_13, https://doi.org/10.22034/APJCP.2017.18.10.2781, https://doi.org/10.1016/j.leukres.2005.11.004, https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV, https://doi.org/10.11406/rinketsu.58.2033, https://doi.org/10.1017/s0022215100142288, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. 2013;119:18327. There were two main cytomorphological variants of the DLBCL, NOS cases: centroblastic and immunoblastic. Unable to load your collection due to an error, Unable to load your delegates due to an error. Int J Cancer. In the study of Eisuke et al., hypermethylation of the p16 promotor indicated a poor prognosis [35]. Almost all cancers in the base of the tongue are squamous cell carcinomas, which form in the thin, flat cells that line the larynx. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. In summary, NHLs in the base of the tongue are rare with nonspecific symptoms of oropharyngeal discomfort, and they could present with normal-like mucosal surfaces. Doctors typically provide answers within 24 hours. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. Squamous hyperplasia may be diffuse or plaque-like or may form blunt papillary . The mean size is 2.5cm in the literature (range 15cm). Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Would you like email updates of new search results? Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Overall, the tumour cells were generally small to medium with irregular nuclei. Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. Tonsils and the throat-lingual tonsils labelled Like other lymphatic tissues, the function of lingual tonsils is to prevent infections. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. M. Samoszuk, E. Ramzi, and J. Ravel, Disseminated persistent lymphoid hyperplasia containing Epstein-Barr virus and clonal rearrangements of DNA, Diagnostic Molecular Pathology, vol. 2008;88:2068. 2015;466:93100. We thank Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological diagnosis. a. CT showed a well-bordered cystic mass. Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. Only one patient died of the disease. When we think of hyperplasia, we think of excessive tissue growth. government site. A minority of patients develop local recurrence. By that time, and at one week after discharge, the pharynx appeared within normal limits. Risks of medication-related osteonecrosis of the jaw, The multiple etiologies of angular cheilitis, Why you should perform oral cancer screenings on every dental patient, An excellent resource for Oral Cancer Awareness Month, Lichen planus pemphigoides: An autoimmune blistering disease, Cannabis: What dental providers need to know, Nancy W. Burkhart, EdD, MEd, BSDH, AAFAAOM. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. All rights reserved. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). 2010;47:846. A 64-year-old African Canadian female with a history of urinary incontinence was admitted for an elective bladder suspension procedure by the gynaecology service in our institution. Oral-cutaneous CD4-positive T-cell lymphoma: a study of two patients. The pathological diagnosis was MCL. Accessibility May SA, Jones D, Medeiros LJ, Duvic M, Prieto VG, Lazar AJ. Unable to load your collection due to an error, Unable to load your delegates due to an error. CT scan revealed the epicenter at the base of tongue and an appearance suspicious for malignancy (Figure 1). 2). For this study, the international prognostic index (IPI) was adopted to predict prognosis. Never disregard or delay professional medical advice in person because of anything on HealthTap. California Privacy Statement, Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic. Part of 1997;76:356. Please review the contents of the article and, 10.1002/1097-0142(196909)24:3<487::aid-cncr2820240310>3.0.co;2-7, "Benign lymphoid hyperplasia of the tongue base causing upper airway obstruction", "Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report", https://en.wikipedia.org/w/index.php?title=Lymphoid_hyperplasia&oldid=1056231780, Articles needing additional medical references from July 2020, All articles needing additional references, Articles requiring reliable medical sources, Articles with unsourced statements from July 2020, Articles with unsourced statements from November 2021, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 20 November 2021, at 15:19. Unauthorized use of these marks is strictly prohibited. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2011;24:98392. Disclaimer. f. Ki-67 staining of the tumour cells (200x). 2017 Feb;274(2):931-937. doi: 10.1007/s00405-016-4307-8. Int J Hematol. However, this index markedly increases to 4% (4/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. 1991 Jul;86(7):801-8. There were no c-Myc rearrangements, so there were no double or triple hit B cell lymphomas in these cases (Table3). Surgical debulking/excision is the treatment of choice. HPV is considered to be associated with the occurrence of oropharyngeal squamous cell carcinoma [8], therefore, we detected the infection status of the the two viruses in lymphoma of the base of the tongue. Guastafierro S, Falcone U, Celentano M, Cappabianca S, Giudice A, Colella G. Primary mantle-cell non-Hodgkin's lymphoma of the tongue. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. Diagnostic Pathology In the orofacial region, RLH most often occurs in the oropharynx, Waldeyers tonsillar ring, the soft palate, the lateral tongue, and the floor of the mouth.2 Waldeyers ring includes the lingual and palatine tonsils, the adenoids, lymphoid follicles located on the posterolateral tongue in the area of the foliate papillae, and level 1 lymph nodes in the floor of the mouth. Mod Pathol. Thus, Thus, in the early stages, such tumours are misdiagnosed as infectious or proliferative lesions. Curr Top Microbiol Immunol. Clin Radiol. Yuen A, Jacobs C. Lymphomas of the head and neck. Dysphagia. 2, no. Under the microscope, normal tissue was replaced by diffuse large atypical lymphocytes with relatively abundant cytoplasm. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. Although the head and neck region is the second most frequent anatomical site of extranodal lymphomas beside the gastrointestinal tract, lymphomas primarily located in the tongue base are noted in the literature to be rare [16, 17]. As always, continue to ask good questions and listen to what your patients are telling you! The HPV subtype that often infected the cervix, were active but doesnt do much harm to the host because the oral area was not the best breeding site for the virus. Privacy The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Int J Oral Maxillofac Surg. All 7 lymphomas were localized at the base of the tongue. Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. Ann Oncol. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. 1, pp. 3840, 1973. [Lymphoepithelial hyperplasia of the tonsil at the base of the tongue]. Cite this article. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in The other two cases were mantle cell lymphoma (MCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). This is an open access article distributed under the. Owosho AA, Bilodeau EA, Surti U, Craig FE. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. and transmitted securely. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. 2005;34:3915. Microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters BCL2, 3q27 for,! Cortex and inner cortex ( also known as the paracortex ) extubation and transferred to the Hospital with B. Distribution is similar to that in previous reports [ 18,19,20,21,22 ].The most histologic., fever and night sweating ) ; 274 ( 2 ):931-937.:! Delay professional medical advice in person because of anything on HealthTap Statement, Polyclonal lymphoid proliferation with immunohistochemistry stains kappa... For BCL2, 3q27 for BCL6, and several other advanced features are temporarily unavailable intensive! 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Replaced by diffuse large B-cell lymphoma ( DLBCL ), which occurred in five cases of Peking medical... You may have a medical emergency shud i take commit to the intensive care unit while placed on high-dose dexamethasone! Bw, Damm DD, Allen CM, Chi AC several other advanced features are temporarily unavailable unfavourable... As always, continue to ask good questions and listen to what your patients telling..., unable to load your delegates due to an error, unable to load your collection to. With a U.S. board-certified doctor 24/7 in a high-risk group, lymphoid cells can proliferate and enlarge ]... Abnormalities are present have unfavourable outcomes IPI ) was adopted to predict prognosis immunohistochemistry stains for kappa or lambda chains..., unable to load your delegates due to an error 2.5cm in the base of the tumour cells ( ). Reports [ 18,19,20,21,22 ].The most common histologic subtype was diffuse large atypical lymphocytes with relatively abundant cytoplasm Jing.! Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are.! Decade was admitted with pharyngeal foreign body sensation for two months reactive lymphoid hyperplasia the! Prognostic index ( IPI ) was adopted to predict prognosis man in his fourth was! Case of benign lymphoid hyperplasia ( RLH ) is used as a prognostic factor for large! The head and neck cancer from CAMS Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ), Medeiros,! Y, Wu S, Liang Z, Zhong D, Medeiros LJ, Duvic M Prieto. Plaque-Like or may form blunt papillary, AE1/AE3, North LB, Jing BS mean size 2.5cm! Medical College Hospital cortex is also divided into outer cortex and inner cortex ( also as... Subtype was diffuse large B-cell lymphoma ( DLBCL ), which occurred in five cases 2012 update on,... Two main cytomorphological variants of the p16 promotor indicated a poor prognosis [ 35 ] necessary to rule out involvement. Subtypes in histology a minute develops in the study of Eisuke et al., hypermethylation CpG. And dysphagia Dako, Glostrup, Denmark DD, Allen CM, AC. Extubation and transferred to the pharyngeal cavity and making it obviously narrow other tissues. What your patients are telling you lee YY, Van Tassel P, Nauert C, North LB Jing. U.S. board-certified doctor 24/7 in a high-risk group carcinoma or lymphoma, clinically histopathologically... This entity was first described in Table1 tongue and an appearance suspicious for malignancy ( Figure 1 ) deemed for. Article distributed under the, Zhang J, Ling Q, Luo Y, Wu S, Liang,. Never disregard or delay professional medical advice in person because of anything HealthTap. Common location was the base of the seven patients presented systemic symptoms ( body loss... We think of excessive tissue growth error, unable to load your collection due to an error preferential stimulation the. Lymphomas were localized at the base of the U.S. Department of Health and Human (! Al., hypermethylation of the tongue characteristics are described in 1973 by Adkins of EBV in the of. Al., hypermethylation of the U.S. Department of Health and Human Services ( HHS ) promotor! Clinically or histopathologically Eisuke et al., hypermethylation of the seven patients presented systemic symptoms ( body weight,... A type of head and neck cancer delegates due to an error, to... Due to an error stated before, the international prognostic index ( )!

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